Diabetes Mellitus:  Lipids



There are currently two agents in this class, Pioglitazone (Actos) and rosiglitazone (Avandia).  The first thiazolidinedione released was troglitazone (Rezulin).  The addition of that medication allowed many Type 2 diabetics to obtain a previously elusive improvement in their glucose control.  Unfortunately, use of troglitazone was associated with occasional elevation in ALT levels and a rare idiosyncratic liver failure.  When the newer agents became available, troglitazone was withdrawn from the market.  Luckily, the two currently available agents have had virtually no significant effects on hepatic enzyme levels nor liver failure.  These drugs can be used as monotherapy or in combination with one or more of the other classes of oral agents or insulin.

Section  Details:


Mechanism of Action


Side Effects



Required Screens:  5

Optional Screens:   6