Because the half-life of serum proteins (average 17 days) is shorter than that of hemoglobin (average 60 days), fructosamine measurements offer the advantage of monitoring glucose status over a shorter time frame (1-3 weeks) than glycated hemoglobin . Serum fructosamine has been shown to be more sensitive than glycated hemoglobin in detecting a deterioration in diabetic control after discontinuing oral hypoglycemic drugs. The fructosamine assay may be run every 2-3 weeks to monitor short-term changes in diabetic control.

The fructosamine test is especially helpful in patients with hemoglobinopathies, where the A1c test gives false results (high or low).

Tests for fructosamine can be done in the laboratory, in the office or by the patient at home.